To look at relationships anywhere between diet and coronary arrest, we utilized Cox proportional potential risks designs stratified of the years (mo) and you may realize-right up period so you’re able to estimate RRs and you can 95% CIs. Users was in fact divided into quintiles from cumulative average intake regarding magnesium, potassium, and you can calcium supplements to attenuate the within-person adaptation and greatest portray enough time-name intake ( 18). A combined nutrient diet plan get out-of magnesium, potassium, and you can calcium were computed by the assigning things to for each and every quintile and you may summing the newest facts. Players on reduced quintile (quintile 1) away from magnesium, potassium, otherwise calcium intake acquired 1 area for every single nutrient, users next quintile (quintile dos) obtained dos affairs, and so on. Cumulative averages had been computed by taking this new imply of all the reported FFQ intakes to the beginning of for every 2-y realize-upwards interval. The cumulative mediocre consumption was applied so you can anticipate heart attack chance off the amount of time of your past came back questionnaire up until the next pursue-up period.
Multivariate activities was adjusted having ages (mo) and you can calendar big date (2-y day periods) and integrated intakes away from full times (kcal), alcoholic beverages (g/d), smoking, Bmi, exercise, parental reputation for very early myocardial infarction, postmenopausal hormone therapy play with, thiazide fool around with, aspirin explore, multivitamin fool around with, and you will reputation of all forms of diabetes, blood pressure levels, and you may hypercholesterolemia from the baseline. To check on for an effective linear development, i assigned for every single quintile new median worthy of and modeled that it changeable since an ongoing adjustable. We checked-out the potential deviation from linearity that with a chances proportion shot to possess comparison off an unit on the linear identity with a model for instance the linear name together with restricted cubic spline changes ( 19). We including conducted analyses you to definitely integrated all the step three vitamins as well. Magnesium and you can potassium intakes had been highly synchronised (r = 0.79 regarding NHS We; roentgen = 0.73 regarding NHS II), and you can correlations anywhere between calcium supplements and you can potassium intakes (roentgen = 0.forty two in the NHS I; roentgen = 0.41 regarding the NHS II), whereas between calcium and you can magnesium intakes (roentgen = 0.54 on the NHS We; roentgen = 0.56 regarding the NHS II) had been modest. Brand new Q decide to try was utilized to evaluate on the heterogeneity anywhere between Rate My Date dating login the fresh NHS We and NHS II. RRs (±SEs) for every quintile out-of for each and every cohort was pooled in the fixed-outcomes models to help you assess summary rates ( 20). Furthermore, new current meta-studies then followed standard practice ( 20) of review for heterogeneity using the Q test and playing with fixed consequences design to manufacture summation quotes whenever no between-education heterogeneity are obvious; if you don’t a haphazard-consequences model was utilized.
To examine the potential effect modification of the association between dietary minerals and stroke risk by age, hypertension, and diabetes, we stratified our multivariate model on age (<60 compared with ?60 y), hypertension (yes compared with no), and diabetes (yes compared with no) and separately tested the significance of an interaction by using a likelihood ratio test for the comparison of the model with interaction terms to the model with only main effects. All P values were 2-sided, and analyses were conducted with SAS 9.2 software (SAS Institute Inc.).
While in the 31 y away from pursue-up out-of 1980 as a result of 2010 from the NHS We and you may twenty two y out of pursue-right up away from 1989 thanks to 2011 from the NHS II, a total of 3780 incident coronary attack cases was in fact ascertained. Of these times, 3237 experience shots was basically documented regarding NHS We (and 1664 ischemic, 544 hemorrhagic, and you will 1029 unspecified strokes), and you may 543 event shots was basically documented on NHS II (plus 186 ischemic, 92 hemorrhagic, and you may 265 unspecified strokes). Age-standardized characteristics out-of research members at midpoint throughout realize-up when you look at the 1994 into the NHS We as well as in 1995 getting new NHS II get within the Desk step 1. Women having highest nutrient consumption had been expected to play with aspirin, nutrients, and you can postmenopausal hormonal cures, much more in person active, less inclined to feel newest cigarette smokers than have been female having down nutrient consumption. Studies for women on the NHS We and NHS II was basically joint since we did not to see a life threatening ranging from-data heterogeneity (Q-fact P > 0.05).